One needs to have an idea about ligands such as ostarine. What is a ligand and how is it significant to the body? Ligand is a molecule or protein that binds to either the receptor of a tissue or the DNA in our bodies to produce a biological result.
One DNA-binding ligand is ostarine, which induces androgen receptors of target sites for the receptors to be able respond to the testosterone. The response of the receptors towards the tissue is called the agonizing effect. This ligand may also make some receptor cells resist the androgenic effect. That case being is known as the antagonistic effect.
Being a DNA ligand, it may be true that if ostarine is taken in more than what is recommended will alter the DNA/RNA structure. Such case of alteration could cause a mutation of cells. Mutation will contribute to cancer development.
The agonistic effects of ostarine are on voluntary muscles and skeletal tissues. This ligand alters the gene transcription of androgen receptors. This case thus impacts the cell’s behavior in the receptors.
Androgen receptors fall under the estrogen receptor-like subfamily, and 3 ketosteroids receptor group. Androgen receptors are grouped along glucocorticoid, mineralocorticoid and progesterone receptors. It is possible for this ligand to affect the other hormones in the adrenal glands as well, despite its selectivity to testosterone. The hormones or enzymes that get affected in the adrenal gland are cortisol, aldosterone, progesterone and estrogen. Thus, ostarine may cause unpleasant effects on blood sugar, blood pressure and estradiol levels in the blood. Using this agent may trigger the development of diabetes due to the action of the cortisol that increases the blood sugar level.
Diabetes mellitus has signs and symptoms of excessive thirst and hunger, frequent urination and blurry vision. Thus, it is recommended that one has his/her blood levels tested before taking in this SARM and before undergoing the PCT cycle. Not only by the time when one starts feeling the things that aren’t usual one should ask his/her blood levels tested.
This SARM not only affects the adrenal glands but the pancreas and liver as well. This agent also affects the hypothalamus by inducing a negative feedback mechanism. That is, if the natural testosterone in the body is forced to the extremes, the message is sent to the hypothalamus to inhibit or halt the pituitary gland in the brain to release LH or Luteinizing hormone. Inhibition of LH release also inhibits the production of testosterone by the testes. This negative feedback may result to low sperm count, or enlarged prostate and dysfunctional gonads/testes (hypogonadism) if PCT or Post Cycle Therapy is not carried out after the 8-week duration of using the agent.
IGF1R or Insulin-like growth factor I receptor and insulin receptor are also the target genes in our DNA of androgen receptor alteration. This alteration may produce cell growth and multiplication of the certain tissues in our body. The action of a burst in testosterone, together with those of the insulin and IGF1R will impact the development of our muscles, bones, joints, nerves, and connective tissues. This is probably why this SARM is taken more on the side of muscle-building and in making the bones dense.
The replication of DNA and/or RNA is a doing of this SARM. This SARM is capable of altering the proteins in a cell. The alteration of protein within the cells enables them to undergo gene transcription or change. This agent may cause a defect in the genes, which have the capacity to infuse the defect to their duplicate. These genes scatter themselves to the different parts of the body like what the oncogenes or cancer genes do.